Ali Can
Woods Hole Oceanographic Institution
Applied Ocean Physics and Engineering Department
MS#7
Woods Hole, MA 02543
 
Work: 508-289-3740
acan@whoi.edu
http://www.cs.rpi.edu/~cana/
Education
Rensselaer Polytechnic Institute, Troy, NY
Ph.D. - Computer, Systems Engineering

8/2000
Thesis title: “Robust computer vision algorithms for registering images from curved human retina.”
M.S. - Electrical Engineering
5/1997
Thesis title: “Rapid automated tracing and feature extraction from live high-resolution retinal fundus images using direct exploratory algorithms.”
Gaziantep University, Gaziantep, Turkey
B.S. - Electrical Engineering
 
6/1993
Honors and Awards
·Microscopy Society of America (MSA) Presidential Student Award, Microscopy & Microanalysis, August 2002,Quebec City, co-recepient.
·MSA Presidential Student Award, Microscopy & Microanalysis, August 2000, Philadelphia, PA.

·MSA Advances in Instrumentation & Techniques 1st Prize, Student Award, Microscopy & Microanalysis, August 2000, Philadelphia, PA.

·The Allen B. DuMont Prize, Rensselaer Polytechnic Institute, May 2000, Troy, NY.

·Best Paper Award, the IEEE Conference on Computer Vision and Pattern Recognition Conference, June 1999, Fort Collins, CO (Out of 500 submissions).

 
Experience
Woods Hole Oceanographic Institution (WHOI), Woods Hole, MA
Postdoctoral Scholar

9/2002-5/2004
Lighting Pattern and Attenuation Correction: Corrected lighting pattern and attenuation in underwater imagery to increase the performance of algorithms in applications such as image registration, quantitative analysis, image enhancement, large-area mosaicing, and change detection. Quantified the performance of different correction algorithms by preparing a test-bed from the overlapping regions of registered images. Collaborated with engineers at WHOI to incorporate these algorithms with HB-LED lighting to revolutionize underwater lighting systems. Enhanced underwater imagery by incorporating attenuation correction and registration algorithms. These algorithms enable scattering free imaging even under very adverse conditions.
Change Analysis of Ocean Floor: Developing registration, segmentation, and classification algorithms to examine a thirteen-year time series of photographs from the deep sea. These algorithms automatically track animal movements to quantify the abundance, size, and activity. These analyses of the longest deep-sea time-lapse sequence will yield insights into deep-sea ecology.
4D Image Analysis and Motion Compensation: Collaborate with researchers at Massachusetts General Hospital (MGH) to design motion-compensated/adjusted treatment planning, and image-guided radiotherapy. Developed algorithms to segment lungs, bones and tissues in 4D CT data. By enabling rapid dose calculations, and accurate radiation delivery, these algorithms can increase the dramatically low success rate in radiation based cancer treatment.
Generalized Ocular Atlases for Ophthalmic Surgery: Constructing 3D ocular atlases to achieve accurate treatment planning. By accurately localizing the tumor relative to the ocular atlas, and relating the exterior of the eye with the interior of the eye, this will lead to real-time computer-assisted treatment methods such as online dosimetry computation on the tumor, and safety shutoff mechanisms. Collaborated with RPI and MGH radiation oncology department for this project.
Rensselaer Polytechnic Institute, Troy, NY 
Research Associate

1/2002-9/2002
Proton Beam Radiation Eye Therapy: Outlined the challenges and prospects related to image-guided proton beam treatment, and ophthalmic treatment planning. Calibrated fundus microscopes, and designed calibration targets for the x-ray system located at the proton-beam facility at MGH. Analyzed different transformation models that represent the imaging system distorted by multiple lenses. Supervised a graduate student (Hari Iyer) to construct a 3D atlas of the eye using a simplified projection model and ray tracing.
Visiting Scholar
6/2001-9/2001
Attenuation Correction in Confocal Laser Microscopes:Developed 3D reconstruction, and 3D robust registration algorithms to extend the lateral and axial dimensions of the confocal microscopy. Achieved attenuation correction, and missing structure recovery by aligning and merging translated and flipped confocal images. Supervised an RPI graduate student, Omar Al-Kofahi, during this project.
Overcoming the fundamental limitations of the confocal microscopes, this novel two-view approach was awarded several awards by Microscopy Society of America.
Research Assistant, Ph.D. Research
8/1997-8/2000
Robust Computer Vision Algorithms: Architected new algorithms to register retinal images, and create retinal mosaics. Achieving accuracy and speed simultaneously, these new algorithms lead to design of revolutionary change detection, and real-time computer assisted treatment algorithms. Some of the contributions of my Ph.D. thesis include; 
·hierarchical robust algorithms for simultaneous image registration and feature correspondence estimation,

·new linear, non-iterative method for jointly estimating the multi-image transformations,

·new transformation model for registering images of curved human retina,

·gradual graph construction algorithm for building up sufficient set of pairwise image correspondences for joint estimation,

·quantitative analysis techniques to measure the performance and accuracy of the algorithms.

Awarded the best paper award by the IEEE Computer Society, and the Allen B. DuMont Prize by RPI, my Ph.D. research leaded to a 1.3 million dollar NSF grant, and NIH R1-trust under the investigation of Prof. Badrinath Roysam. The ongoing efforts at RPI are referred to as the retina project @ RPI which has yielded several Ph.D. dissertations, and many publications and citations.

Research Assistant, MS Research
1/1995-8/1997
Exploratory Feature Extraction Algorithms (MS Thesis): Designed a template-based exploratory tracing algorithm for automatic, rapid and accurate tracing of retinal vasculature. Achieved accuracy and speed simultaneously by producing monotonically improving sequence of usable partial results, and directly processing on the gray level data without any pre-processing. Enabled the design of deadline-driven real-time computer assisted treatment instrumentation.
Through recent Ph.D. dissertations at RPI, this frequently cited algorithm has been extended to build efficient and accurate 2D and 3D algorithms for tracing neurons and vasculature. An FPGA hardware implementation of this algorithm has recently been built at Boston University.
Pharmaceutical Imaging Applications: Developed and implemented stage control, camera calibration and feature extraction units of an automated Syrian Hamster Embryo cell transformation assay classification system. Supervised several graduate and undergraduate students to build parts of this real-time vision system.
Inonu University, Malatya, Turkey 
Instructor

8/2000-12/2001
Taught sophomore level probability class, and senior level digital communications, and antenna theory classes. Participated in curriculum development activities in the Electrical Engineering Department. Prepared a report on ABET substantial equivalency requirements.
 
Affiliations and Committee Involvement
NSF ERC, Center for Subsurface Sensing and Imaging Systems (CenSSIS).
Member, IEEE Computer Society, Oceanic Engineering Society, and Microscopy Society of America.
Reviewer for IEEE Journal of Oceanic Engineering, IEEE Transactions on Biomedical Engineering, and IEEE Transactions on Information Technology in Biomedicine.
The ORION Workshop participant in Primary Productivity and Ecology, and Engineering and Technology groups, January 2004, San Juan, Puerto Rico.
 
Research Cruises
Oxygenated and Anoxic waters of Black Sea, Sinop, Turkey, Chief Scientist R. Ballard, RV Knorr, “Deep underwater archaeology,” three weeks in August 2003. (This cruise appeared as a featured article in May 2004 issue of National Geographic Magazine)
Marine Conservation District Hind Bank and the South Drop, St. Thomas and St. John in the US Virgin Islands, Chief Scientist H. Singh, RV Chapman, “Deepwater coral reefs research,” one week in June 2003.
Stellwagen Bank Marine Sanctuary Region, Boston, Massachusetts, Chief Scientist H. Singh, RV Oceanus, “Geologic and Benthic-Habitat Studies of the Sea Floor,” one week in March 2003.
 
Journal Publications
Al-Kofahi, K., A. Can, S. Lasek, D. H. Szarowski, N. Dowell, W. Shain, J. N. Turner, B. Roysam “Median Based Robust Algorithms for Tracing Neurons from Noisy Confocal Microscope Images,” IEEE Transactions on Information Technology in Biomedicine, vol. 7, no. 4, pp. 302-317, December, 2003.
Can, A., O. Al-Kofahi, S. Lasek, D. H. Szarowski, J. N. Turner, B. Roysam, “Attenuation Correction in Confocal Laser Microscopes: A Novel Two-view Approach,” Journal of Microscopy, vol. 211, pp. 67-79, July 2003.
Al-Kofahi, O., A. Can, S. Lasek, D. H. Szarowski, J. N. Turner, B. Roysam, “Registration of 3-D Neuron Images Acquired by Confocal Scanning Laser Microscopes,” Journal of Microscopy, vol. 211, pp. 8-18, July 2003.
Can, A., C. V. Stewart, B. Roysam, H. L. Tanenbaum, “A Feature-Based Technique for Joint, Linear Estimation of High-Order Image-to-Mosaic Transformations: Mosaicing the Curved Human Retina,” IEEE Transactions on Pattern Analysis and Machine Intelligence, vol. 24, no. 3, pp. 412-419, March 2002.
Can, A., C. V. Stewart, B. Roysam, H. L. Tanenbaum, “A Feature-Based, Robust, Hierarchical Algorithm for Registering Pairs of Images of the Curved Human Retina,” IEEE Transactions on Pattern Analysis and Machine Intelligence, vol. 24, no. 3, pp. 347-364, March 2002.
Turner, J. N., W. Shain, D. H. Szarowski, S. Lasek, N. Dowell, B. Sipple, A. Can, K. Al-Kofahi, B. Roysam, “Three-Dimensional Light Microscopy: Observation of Thick Objects,” The Journal of Histotechnology, vol. 23, no. 3, pp. 205-217, September 2000.
Can, A., H. Shen, J. N. Turner, H. L. Tanenbaum, B. Roysam, “Rapid Automated Tracing and Feature Extraction from Live High-Resolution Retinal Fundus Images Using Direct Exploratory Algorithms,” IEEE Transactions on Information Technology in Biomedicine, vol. 3, no. 2, pp. 125-138, June 1999.
Turner, J. N., W. Shain, D. H. Szarowski, S. Lasek, B. Sipple, C. Pace, K. Al-Kofahi, A. Can, B. Roysam, “Confocal Light Microscopy of Brain Cells and Tissue: Image Analysis & Quantitation,” Acta Histochemica et Cytochemica, vol. 32, No. 1, pp. 5-11, 1999.
Becker, D. E., A. Can, H. L. Tanenbaum, J. N. Turner, B. Roysam, “Image Processing Algorithms for Retinal Montage Synthesis, Mapping, and Real-Time Location Determination,” IEEE Transactions on Biomedical Engineering, vol. 45, no. 1, pp. 105-118, January 1998.
 
Book Chapters
Fritzsche, K., A. Can, H. Shen, C. Tsai, J. N. Turner, H. L. Tanenbaum, C. V. Stewart, B. Roysam “Automated Model-Based Segmentation, Tracing, and Analysis of Retinal Vasculature from Digital Fundus Images,” Angiography and Plaque Imaging, Advanced Segmentation Techniques, CRC Press, pp. 225-297, 2003.
Becker, D. E., A. Can, H. L. Tanenbaum, J. N. Turner, B. Roysam, “Image Processing Algorithms for Retinal Montage Synthesis, Mapping, and Real-Time Location Determination,” IMIA Yearbook of Medical Informatics, International Medical Informatics Association, Schattauer Press, Germany, (Bemmel et al., eds), pp. 433-446, 1999.
 
Conference Publications
Paganetti, H., E. Rietzel, A. Can, H. Singh, G. T. Y. Chen, “Real Four-Dimensional Monte Carlo Dose Calculation for Double-Dynamic Systems (Time-Dependent Delivery Under Organ Motion),” Medical Physics, vol. 30, page 1451 (Abstract), San Diego, CA, August 2003.
Paganetti, H., E. Rietzel, A. Can, H. Singh, G. T.Y. Chen, “Simulation of four-dimensional effects in radiation therapy: The dose in intensity modulated beam delivery under organ motion,” International Journal of Radiation Oncology, Biology, and Physics, Salt Lake City, Utah, October 2003.
Al-Kofahi, O., A. Can, S. Lasek, D. H. Szarowski, J. N. Turner, B. Roysam, "Multi-View Three-Dimensional Image Montaging & Signal Attenuation Correction for Maximizing the Imaging Depth and Lateral Extend of Confocal Microscopes," Proceedings Microscopy and Microanalysis, Microscopy Society of America 60th Annual Meeting, Quebec City, Canada, pp. 1042-1044, August 2002. (MSA Presidential Student Award, co-recipient)
Can, A., S. Lasek, D. H. Szarowski, J. N. Turner, B. Roysam, “A Robust Two-View Method for Increasing the Imaging Depth and Correcting for Signal Attenuation in Confocal Microscopes,” Proceedings Microscopy and Microanalysis, Microscopy Society of America 58th Annual Meeting, Philadelphia, Pennsylvania, pp. 818-819, August 2000. (MSA Presidential Student Award)
Can, A., C. V. Stewart, B. Roysam, H. L. Tanenbaum, “A Feature-Based Technique for Joint, Linear Estimation of High-Order Image-to-Mosaic Transformations: Application to Mosaicing the Curved Human Retina,” Proceedings IEEE Computer Society Conference on Computer Vision and Pattern Recognition, Hilton Head Island, South Carolina, pp. 585-591, June 2000.
Can, A., C. V. Stewart, B. Roysam, “Robust Hierarchical Algorithm for Constructing a Mosaic from Images of the Curved Human Retina,” Proceedings IEEE Computer Society Conference on Computer Vision and Pattern Recognition, Fort Collins, Colorado, pp. 286-292, June 1999. (Best Paper Award)
Roysam, B., A. Can, H. Shen, J. N. Turner, “From 3-D Light Microscopic Images to Quantitative Insight,” Proceedings Microscopy and Microanalysis, Microscopy Society of America 57th Annual Meeting, Portland, Oregon, pp. 524-525, August 1999.
Turner, J. N., W. Shain, D. H. Szarowski, S. Lasek, L. Kam, A. Can, K. Al-Kofahi, B. Roysam, “Three-Dimensional Light Microscopy: Imaging & Corrections for Quantitative Analysis,” Proceedings Microscopy and Microanalysis, Microscopy Society of America 57th Annual Meeting, Portland, Oregon, pp. 522-523, August 1999.
Can, A., H. Shen, K. Al-Kofahi, J. N. Turner, H. L. Tanenbaum, B. Roysam, “Rapid, Automated, and Robust Tracing of Vasculature, and Quantification of Visual Features from Angiographic Images,” Proceedings Microscopy and Microanalysis, Microscopy Society of America 55th Annual Meeting, Cleveland, Ohio, pp. 325-326, August 1997.
 
Manuscripts Submitted and in Preparation


 

Can, A., H. Singh, “Methods for Correcting Lighting Pattern and Attenuation in Underwater Imagery,” submitted for review to IEEE Journal of Oceanic Engineering, May 2004.
Singh, H., A. Can, E. Ryan, S. Lerner, N. McPhee, O. Pizarro, C. Roman, “The Seabed AUV: A new platform for High Resolution Imaging,” submitted for review to EOS, Transactions, American Geophysical Union, May 2004.
Can, A., H. Singh, G. Yang, B. Roysam, C. V. Stewart, “Optimal Blending Algorithms for Large-area Color Mosaics,” in preparation for IEEE Transactions on Pattern Analysis and Machine Intelligence.
Beaulieu, S.E., A. Can, H. Singh, K.L. Jr. Smith, “Analyzing Time-lapse Photographs of the Sea Floor for Changes in Benthic Community Activity,” in preparation for Limnology and Oceanography: Method.
Can, A., H. Singh, G. Yang, G. Lin, B. Roysam, C. V. Stewart, G. Chen, J. M. Collier, “Construction of 3-D Generalized Ocular Atlases,” in preparation for Journal of the Optical Society of America A – Optics, Image Science, and Vision.
 
A Few Pictures